I agree with posters above. I used to rack up 250K miles a year. Here's a few tips:
1. Hydrate well: before (days before too), during, and after flight. Always buy a bottle of water once you get through security. No matter how long your flight is, if there is bad turbulence, the pilot will order the flight crew to remain seated and that could be a long time before that drink cart makes it way around.
2. Pack snacks... never know when the plane will be delayed (on tarmac), or diverted.
3. Stay off junk food (empty calorie types)... spend the extra money on fruits/nuts, etc, if you find yourself in need of something in the airport.
4. Get up and stretch often, especially your legs/feet. Keep yourself in shape... it helps with long flights.
5. Wear loose fitting clothes, slip on shoes (like Crocs... they may look stupid but are perfect for long flights)
6. Pack at least a change of clothes in a carry on, especially underwear. A great brand is Ex Officio... $25 a pair but they are the most comfortable and made for endurance travel.
7. Pack small toiletry items (TSA-approved containers)
8. Pack a roll-up, quality pillow. REI
sells some nice ones.
9. Baby wipes... buy 'em, pack 'em, use 'em. Trust me.
10. Luggage: Don't buy a black suitcase. Everyone has one, therefore making yours tough to distinguish among hundreds of others. Get something that will stand out so you can spot it right away and get the hell out of the airport faster.
11. One more: Use a site like SEATGURU.COM to look at the seat you are assigned and it will tell you if there any problems with it on a specific type of aircraft. For example, if your seat happens to not recline or some bullshit like that.
Good luck... sounds like a great new adventure for you.