My wife is handicapped, and has trouble getting into cars and especially trucks. I ordered a factory running board for my Prerunner for this reason. She still need a step stool, the running board being too high for her to manage, but useful in conjunction with the step stool, as well as for my washing the truck and loading the roof rack.
For myself, getting in and out is more of a hassle with the runningboards, as I scrape my legs as I bypass the boards. If I had it to do over, I'd leave off the boards for my comfort, and have my wife use the step stool to wash my truck!