The Official Gym & Fitness Thread

And if your body will stop making everything on its own if you don't cycle off

 

long one but I'm bored at work so here's what I dug up about creatine and the need to cycle.. highlights address what each article found

Mol Cell Biochem. 1998 Jul;184(1-2):427-37.
Creatine supplementation in health and disease. Effects of chronic creatine ingestion in vivo: down-regulation of the expression of creatine transporter isoforms in skeletal muscle.

Interest in creatine (Cr) as a nutritional supplement and ergogenic aid for athletes has surged over recent years. After cellular uptake, Cr is phosphorylated to phosphocreatine (PCr) by the creatine kinase (CK) reaction using ATP. At subcellular sites with high energy requirements, e.g. at the myofibrillar apparatus during muscle contraction, CK catalyzes the transphosphorylation of PCr to ADP to regenerate ATP, thus preventing a depletion of ATP levels. PCr is thus available as an immediate energy source, serving not only as an energy buffer but also as an energy transport vehicle. Ingestion of creatine increases intramuscular Cr, as well as PCr concentrations, and leads to exercise enhancement, especially in sprint performance. Additional benefits of Cr supplementation have also been noticed for high-intensity long-endurance tasks, e.g. shortening of recovery periods after physical exercise. The present article summarizes recent findings on the influence of Cr supplementation on energy metabolism, and introduces the Cr transporter protein (CreaT), responsible for uptake of Cr into cells, as one of the key-players for the multi-faceted regulation of cellular Cr homeostasis. Furthermore, it is suggested that patients with disturbances in Cr metabolism or with different neuro-muscular diseases may benefit from Cr supplementation as an adjuvant therapy to relieve or delay the onset of symptoms. Although it is still unclear how Cr biosynthesis and transport are regulated in health and disease, so far there are no reports of harmful side effects of Cr loading in humans.However, in this study, we report that chronic Cr supplementation in rats down-regulates in vivo the expression of the CreaT. In addition, we describe the presence of CreaT isoforms most likely generated by alternative splicing.

Mol Cell Biochem. 2003 Feb;244(1-2):159-66.
Acute and moderate-term creatine monohydrate supplementation does not affect creatine transporter mRNA or protein content in either young or elderly humans.

Animal studies have shown that supra-physiological creatine monohydrate (Cr-mH) supplementation for 3 months reduced skeletal muscle creatine transporter (CRT) content. The doses of Cr-mH (1-2 g/kg/day) used in these studies were between 5 and 10 times those usually used in human studies, and it is unclear whether a down-regulation of CRT would occur in humans at the recommended doses of 0.1-0.2 g/kg/day. We measured CRT, and citrate synthase (CS) protein content using Western blotting before and after 2 months of Cr-mH supplementation and weight training in young men (N = 11 Cr-mH (0.125 g/kg/ day); N = 8 placebo). CRT and CS were also measured before and after 4 months of Cr-mH supplementation and weight training in elderly (> 65 years) men and women (N = 14 Cr-mH (0.075 g/kg/day); N = 14 placebo). Finally, CRT mRNA was measured using competitive RT-PCR before and after 8-9 days of Cr-mH loading in young men and women (N = 14, CR-mH (mean = 0.18 g/kg/day); N = 13, PL). Total creatine content was significantly elevated after the Cr-mH supplementation period as compared to placebo in each of the studies. Neither Cr-mH supplementation, nor exercise training resulted in measurable alterations in CRT protein content and acute Cr-mH loading did not alter CRT mRNA. There were no gender differences in CRT mRNA or total creatine content in the young subjects and no gender differences in total creatine content or CRT protein content in the elderly subjects. Weight training in young men did not increase CS protein content, however, in the elderly there was a significant increase in CS protein content after exercise training (p < 0.05). These results demonstrated that Cr-mH supplementation during weight training resulted in increases in skeletal muscle total creatine without reductions in CRT protein and acute Cr-mH loading did not decrease CRT mRNA content.

 

TL;DR

 

Somebody post cliffs

 

I didn't understand all the technical lingo but I think the jist was it benefited elderly more than younger men? It's basically Cialis...

 

I take 3 viagra with my pre workout

 

Makes 1 arm push-ups easier

 

Damn right it does. Huge test boost as well.

 

I guess you could say....





You like to go hard




YEEEEEAAAAAAAAAHHHHHHHHHH

 

x2. Did read, didn't understand.

 

Down from 206 to 204 in 2 days of my cut. I know it's just water-weight, but I still don't like the scale moving that fast! I'm gonna press on until next week and if I lose more than a pound next week, I'm gonna up the calories by about 100. So far, the only cheating I've done has been a few peppermints and a handful of boiled peanuts. Tomorrow is the last day of legislative session here in GA and everyone always brings all kinds of food and drinks...tomorrow will be the ultimate test.

 

Got my triad and white flood well it's called white Rapids now evidently today. It's not a regular pre right? It's more of a pump enducer right ?

 

I feel your pain,
Im rocking something in that same range and will be attempting to loose about 20# of fat to get me as lean as possible at 220...... 240 right now. Gonna try stick to 3k with specific macros and see how she goes. No cardio either at this point but just High interval weight training utilizing 3 big muscle groups with limited rest for about 50 min.

for shits and giggles, I'm gonna use the Biometric scanner thingy at the gym and keep a print out every week( gonna run 3 scans per day for better accuracy on the scanners) to see if I'm loosing in the right places. I don't mind the machine not being accurate, i just need it to be consistent

 

I've done dumber things before lol.

 

Just got back this morning from vacation and haven't been to the gym in about a week. Stoked to go hit upper body hard. Kinda want to see my max on bench. What do you guys think about checking max weights on the Smith machine since I don't have a spotter 99% of the time?

 

Also I found my new fucking Jam. Pretty fucking gay but Ariana Grande's dangerous woman has been blasting in my head phones all week and I can't get enough of it.

 

Bench on the smith's is a completely different exercise. If you want to test out your max, just ask a random to spot you.

 

Also, nothing gay about listening to Ariana as long as you're thinking about sliding your mushroom tip in those sugar walls while you listen.