4wd wheel spacers vs. 2wd wheel spacers

Looking to get some wheel spacers my for 2019 trd off road 4x2. A lot of stores online say the spacers are not compatible with the 2wd, only fit 4wd. Is this really true? I don’t see any difference in the specs...6 lug, 6x139.7.
Thanks

 

I’ve had spacers on my 2wd for over 10k miles now and no issues

 

Are they listed as 2005-2020?
2nd gen used to have a 2wd 5-lug(base) and 2wd 6-lug(Prerunner).
You should be good.

 

Yes listed as 05-20. So is it just the lug pattern that makes the difference?

 

I'm not gonna say anything bad will happen if you install them but..

(Third Gens are all 6 lug. 2wd, 4x4, 6wd, even the unicycle model. All 6 bolt.)