Still think TITNC3: Return of the Iceberg was peak

CowboyTaco · Jun 3, 2022

I've been looking at fertilizer companies after reading an article about them being well positioned to endure a recession. With the recent disruption in supply of wheat and other farm goods, domestic farmers are going to need their fertilizers. The companies can pass on rising cost to consumers, who pretty much need it to stay competitive. The three that have been most highly recommended, or at least by a handful of articles that I've read, are CF, MOS and IPI.

CF and MOS pay a dividend. IPI is +121% over the past 52 weeks compared to CF (+77%) and MOS (+60%). MOS has the lowest P/E and the lowest equity score of the three, but is still pretty darn good at 8.9.

I already picked up some CF and am torn between the other two.

....and for all you meme guys, even the gourd farmers will need their fertilizer....

BudFriendguy · Jun 3, 2022

I have to pee.

montijo505 · Jun 3, 2022

BudFriendguy said: ↑

I have to pee.
Click to expand...

I think he just said he has to pee.

Fohu · Jun 3, 2022

@CowboyTaco I’m heavily invested in a worm farm for my fertilizer needs. Ewc

TreeFortRichard · Jun 3, 2022

OK..
$NVAX stock down on the FDA wanting a myocarditis warning for their mRNA vaccine...
This is a bizarre story...Look at this
WTF is going on here...
You have the may 22 LA Times article in direct opposition to the FDA warning. Why would this story ever get run?

With old-school technology, can Novavax win over COVID vaccine skeptics?

A vial of the Novavax COVID-19 vaccine is ready for use in a Phase 3 clinical trial in London.
(Alastair Grant / Associated Press)
By Melissa HealyStaff Writer
May 16, 2022 5 AM PT
Since their debut just 18 months ago, three COVID-19 vaccines have saved an estimated 2.2 million American lives, changed the trajectory of a pandemic and inspired all manner of conspiracy theories.

Two of those shots prompt a recipient’s own cells to manufacture a key piece of the coronavirus by following instructions encoded in messenger RNA, or mRNA for short. The vaccines developed by Pfizer and Moderna have revolutionized our approach to immunizations, and they’ve done so with blinding speed.

That’s left many people yearning for something a bit more old-school.

A COVID-19 vaccine from Novavax could fit that bill. In a world of newfangled ideas about training the immune system to spot and defend against an invading virus, the Novavax vaccine does it the old-fashioned way: by introducing an exact replica of the coronavirus spike protein into the bloodstream to show the immune system what the invader looks like.
Add in an “adjuvant” — an immune-boosting substance made from the purified bark of a South American tree — and, voilà! You’ve got the type of vaccine Americans have been taking for years to protect against familiar scourges like influenza and shingles.

Yes, there are nanoparticles and synthetic “recombinant proteins” involved. Legions of precisely uniform spike particles are manufactured not inside chicken eggs but in the cells of the Army caterpillar. These are hallmarks of a 21st century vaccine, one that was developed and tested under the aegis of Operation Warp Speed.

But Novavax touts its technology as a “well-known and established platform” for building vaccines. It expects its product known as NVX-CoV2373 to be embraced by Americans who are still suspicious of the mRNA mainstays, or are disinclined to turn to them as boosters.

Those skeptics run the gamut, from people who think the mRNA vaccines were developed and tested too quickly to detect potential long-term side effects (a plausible concern) to those who believe they implant movement-tracking microchips into recipients’ bodies (a fear without any supporting evidence). In between are folks worried about the vaccines’ impact on fertility (current evidence shows no reason to be concerned) and those afraid that they alter a recipient’s DNA permanently (not possible, since the vaccine doesn’t enter a cell’s nucleus, where DNA resides).

Some people “may prefer tried and true technologies” for COVID-19 vaccines, said Dr. Filip Dubovsky, the chief medical officer of Novavax. While declaring himself a fan of mRNA vaccine technology, he added that others “may not like the concept of ... turning their body into a little vaccine factory.”

If made available, the Novavax vaccine might induce some of the millions of still-unvaccinated Americans to roll up their sleeves at last. “And when everybody gets vaccinated thoroughly, that’s when we get to tamp down” the coronavirus’ spread, he said.

Dr. Gregory Poland, a Mayo Clinic vaccinologist who has consulted with Novavax and other COVID-19 vaccine manufacturers, described NVX-CoV2373’s marketing niche a bit more directly.

“This would not be a ‘genetic vaccine,’” Poland said. “And people wary of ‘genetic vaccines’ might find it more appealing.”

That’s not its only upside. The Novavax vaccine does not seem to induce the rare but potentially serious type of heart inflammation associated with the mRNA vaccines. Nor does it cause the strong reactions that prompted some people who got the mRNA vaccines to put off their booster shots. Plus, some anti-abortion activists who refuse to take the mRNA vaccines because they were developed with cells lines derived from an aborted fetus would see it as an acceptable alternative.

But first, the U.S. Food and Drug Administration needs to authorize the vaccine for emergency use, and the Centers for Disease Control and Prevention must recommend it.

Why that has taken so long is a mystery. The Novavax vaccine — known commercially as Nuvaxovid or Covavax — is already authorized for emergency use in 28 countries and endorsed by the World Health Organization.

“This is a very good vaccine, but the FDA has slow-walked it every step of the way,” said Georgetown University’s Lawrence Gostin, an expert in public health law. Manufacturing hiccups raised early concerns among U.S. regulators. But those have long since been resolved, and Novavax has said it is on track to produce 2 billion doses this year.

Unlike the shots made by Pfizer-BioNTech and Moderna, NVX-CoV2373 doesn’t require refrigeration at ultra-cold temperatures. It is formulated so that it does not need to be reconstituted, making it easier to administer by less-skilled handlers. And it can be produced cheaply and reliably by pharmaceutical manufacturers across the world.

All of those attributes make it likely that the Novavax vaccine will play an important role in running up vaccine coverage in the world’s low- and middle-income countries.

“Having the FDA authorize it in the United States would boost confidence in this vaccine globally,” Gostin said. That, in turn, could help avert surges and impede the emergence of new coronavirus variants, he said.

One forward-looking move by Novavax could make its candidate a bit more appealing to U.S. regulators.

The packaging of its immunological payload is so efficient that it leaves room to protect against more than one disease. The company, which has a long history of making flu vaccines, announced in late April that it has begun human trials of a combination shot designed to induce immunity not only against COVID-19 but four different strains of influenza as well. It’s even possible a single Novavax shot could target multiple coronavirus variants in one shot, although Dubovsky said it makes sense to use the shots to protect “against two diseases with one jab.”

Novavax has produced and distributed 44 million doses of its purely COVID-19 vaccine since December 2021, and they’ve been going into arms in a wide range of countries. Indonesia, South Korea, Australia and the European Union were among its first big customers, and Japan joined the list last month. Manufacturers in Japan and India are are contracted to produce hundreds of millions of doses.

In clinical trials, side effects tied to NVX-CoV2373 have been mild and infrequent. The most common complaints were injection site pain, headaches and fatigue. And though mRNA vaccines have been linked to myocarditis in male adolescents and young adults, no cases of the potentially dangerous heart inflammation have been detected in the Novavax trials.

Though its widespread use abroad is building confidence in the vaccine’s safety, its effectiveness in protecting against COVID-19 — and especially against illness caused by the Omicron variants that now dominate the world — will be an object of intense scrutiny by U.S. regulators when they meet on June 7.

One of the two clinical trials the Food and Drug Administration and its vaccine advisory committee will examine involved 30,000 adults in the United States and Mexico, and it found the shots 100% effective in protecting against mild and moderate cases of COVID-19.

But that trial was conducted at a time when the original coronavirus strain was waning, and the Alpha variant and others were becoming established. Against those variants, the vaccine efficacy declined somewhat, to 92.6%.

In a second clinical trial conducted in U.S. and Mexican adolescents ages 12 to 17, the Novavax vaccine had an overall efficacy of 80% in preventing COVID-19, largely against the trickier Delta variant. When compared with adults who got the vaccine, the teens’ immune responses were about two to three times higher against all variants studied, suggesting it may be well-suited to younger Americans.

Novavax has not submitted a clinical trial that reflects its vaccine’s success against the Omicron variant. Dubovsky argued that the vaccine’s steady rate of efficacy across a wide range of variants augurs well for its ability to protect not only against Omicron, but against others that may crop up.

Gostin said U.S. officials “have just bet the farm on the two mRNA vaccines,” but it’s not too late to add others to the mix. Use of the Johnson & Johnson vaccine has stalled since the CDC declared the Pfizer and Moderna vaccines “preferred ... in most circumstances.” AstraZeneca’s COVID-19 vaccine has never been evaluated by the FDA for the U.S. market, even though 2.6 billion doses have been delivered across the globe.

“I
Click to expand...

U.S. FDA flags risk of heart inflammation after Novavax COVID vaccine

By Manas Mishra
and Mrinalika Roy

2 minute read

1/2
A vial labelled "Novavax COVID-19 Vaccine" is seen in this illustration taken January 16, 2022. REUTERS/Dado Ruvic/Illustration

Register now for FREE unlimited access to Reuters.com
June 3 (Reuters) - U.S. Food and Drug Administration staff said on Friday they were concerned about a possible risk of heart inflammation from Novavax Inc's (NVAX.O) vaccine, even as the company's data showed the vaccine was effective in reducing the risk of mild-to-severe COVID-19.

In the company's nearly 30,000 patient trial, conducted between December 2020 and September 2021, there were four cases of myocarditis, a type of heart inflammation also associated with mRNA vaccines, detected within 20 days post vaccination.

One patient in the trial reported myocarditis after receiving placebo.

"These events raise the concern for a causal association with this vaccine, similar to the association documented with mRNA COVID19 vaccines," the FDA staff wrote in briefing documents released on Friday.

Shares of the company fell nearly 14% after the FDA's analysis of data from the company's trial.

The FDA said it had requested Novavax to flag myocarditis and another kind of heart inflammation called pericarditis as an "important identified risk" in its materials. The company had not yet agreed to do so.

Novavax said the number of myocarditis events in its clinical trial was "within the range of expected background cases."

Novavax has said its protein-based shot will play a role in driving vaccination among those who have been hesitant to get immunized and it has started an educational effort on vaccine choices.

"Despite the wide availability of authorized or approved vaccines, the SARS-CoV-2 pandemic is not well controlled in the U.S. ... there remains a desire for vaccines that have been developed using well-understood technology platforms," it said.

The FDA analyzed data from Novavax's trial before the Omicron and Delta variant became the dominant strains.

"Based on the efficacy estimate in the clinical trial of this vaccine, it is more likely than not that the vaccine will provide some meaningful level of protection against COVID-19 due to Omicron, in particular against more severe disease," the FDA staff said.

The comments came in a briefing note initially prepared ahead of a May 7 meeting of the FDA's outside advisers. The FDA staff comments will be used by those advisers to guide their decision on whether or not to recommend authorizing the vaccine on Tuesday. The FDA is not mandated to follow the advise of its outside experts, but usually does.

In the company's study, which enrolled about 30,000 adults in the United States and Mexico, the vaccine had an efficacy of 90.4%.
Click to expand...

TreeFortRichard · Jun 3, 2022

$CRUDE going to bust that 52w cherry today?

TreeFortRichard · Jun 3, 2022

Closed that $GME Put

jandrews · Jun 3, 2022

lol GME thinking positive today.

kairo · Jun 3, 2022

TreeFortRichard said: ↑

OK..
$NVAX stock down on the FDA wanting a myocarditis warning for their mRNA vaccine...
This is a bizarre story...Look at this
WTF is going on here...
You have the may 22 LA Times article in direct opposition to the FDA warning. Why would this story ever get run?

Click to expand...

Calls on the Grinch

enforcertaco91 · Jun 3, 2022

https://www.youtube.com/watch?v=HmuRjCGKBw4

Facts on gold thru history ... uh ohh Bob is spilling too many beans, this vid is worth a watch b4 it magically disappears.

kairo · Jun 3, 2022

enforcertaco91 said: ↑

https://www.youtube.com/watch?v=HmuRjCGKBw4

Facts on gold thru history ... uh ohh Bob is spilling too many beans, this vid is worth a watch b4 it magically disappears.
Click to expand...

The best place he could think to do an interview was with his clothes closet reflected in a mirror?

98tacoma27 · Jun 3, 2022

kairo[OP] said: ↑

The best place he could think to do an interview was with his clothes closet reflected in a mirror?

Click to expand...

At least you can't see his dildo.

kairo · Jun 3, 2022

98tacoma27 said: ↑

At least you can't see his dildo.
Click to expand...

haaah

He seems paranoid enough that could be a reinforced basement or a bunker

TreeFortRichard · Jun 3, 2022

Oooof...
Take the under on $DKNG today?

TreeFortRichard · Jun 3, 2022

kairo[OP] said: ↑

haaah

He seems paranoid that could be a reinforced basement or a bunker
Click to expand...

My thoughts...his shelter...sitting on bars of gold

kairo · Jun 3, 2022

TreeFortRichard said: ↑

My thoughts...his shelter...sitting on bars of gold
Click to expand...

king midas in shambles

kairo · Jun 3, 2022

TreeFortRichard said: ↑

My thoughts...his shelter...sitting on bars of gold
Click to expand...

hahahahahhahahahah YOU WERE RIGHT
30 minute mark: "I can put my hands on $50,000 worth of gold in about 30 seconds"

TreeFortRichard · Jun 3, 2022

kairo[OP] said: ↑

hahahahahhahahahah YOU WERE RIGHT
30 minute mark: "I can put my hands on $50,000 worth of gold in about 30 seconds"
Click to expand...

Eccentric codpiece...

TreeFortRichard · Jun 3, 2022

They trying to sink $GME below those 600,000 contracts in the money at $130....Could have saved $400 dollars closing it now...right?

98tacoma27 · Jun 3, 2022

TreeFortRichard said: ↑

They trying to sink $GME below those 600,000 contracts in the money at $130....Could have saved $400 dollars closing it now...right?
Click to expand...

They're probably naked contracts.

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kairo [OP] >_>

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TreeFortRichard Barcelona Red is the best red...

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TreeFortRichard Barcelona Red is the best red...

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#71177
kairo [OP] >_>

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Still think TITNC3: Return of the Iceberg was peak

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#71168 jandrews Hootin' and Hollerin'

#71169 kairo [OP] >_>

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Products Discussed in Entire Site Forum: Stocks & Investments Thread: Still think TITNC3: Return of the Iceberg was peak

#71161
CowboyTaco $20 is $20

#71162
BudFriendguy TRD BRGLR

#71163
montijo505 Moon soon?

#71164
Fohu Well-Known Member

#71165
TreeFortRichard Barcelona Red is the best red...

#71166
TreeFortRichard Barcelona Red is the best red...

#71167
TreeFortRichard Barcelona Red is the best red...

#71168
jandrews Hootin' and Hollerin'

#71169
kairo [OP] >_>

#71170
enforcertaco91 Well-Known Member

#71171
kairo [OP] >_>

#71172
98tacoma27 is going full "SANDWICH" Moderator

#71173
kairo [OP] >_>

#71174
TreeFortRichard Barcelona Red is the best red...

#71175
TreeFortRichard Barcelona Red is the best red...

#71176
kairo [OP] >_>

#71177
kairo [OP] >_>

#71178
TreeFortRichard Barcelona Red is the best red...

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TreeFortRichard Barcelona Red is the best red...

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