general auto question

I have a friend who brought a good running crown vic with 4.6l from Denver to va on a trailer. Upon arriving and driving the car, it got a check engine light with bad shaking. Codes say misfire on 2 of the cylinders. Also said that Denver has 85 octane, which the car has in it.
MY QUESTION - could going from that elevation to sea level cause this? Having not driven it from that elevation didn't give the ecu time to re-learn. Or could it be as simple as the lower octane?

 

The lower octane shouldn't be the issue.....you shouldn't need as high an octane rating to suppress knock when you're at higher elevation. That said, it can't hurt to put in a higher octane and prove me wrong. That's where I'd start anyway.

I'm interested to hear if anybody else has run into this

 

Also possible it may take the computer a while to compensate for the change in altitude and lower O2. I’d also pull the plugs to see what they look like.

 

Cars check the barometric pressure each time the vehicle starts, I think that newer Ford cars (last few years) do it about once a hour for long trips. I would recommend clearing codes and seeing if they would return, If you want to try higher octane go ahead by all means but its rather unlikely. Which cylinders are missing? fords numbering goes looking at the crankshaft pulley, left bank 1, 2, 3, 4, front to back, then right bank 5, 6, 7, 8 front to back.