Looking for little guidance on next step - P0301 code

I have a 2011 with a 4 cylinder. The CEL came on the other day and I saw a P0301 and a P0302 code. I replaced the plugs (they looked pretty good so I feared this wasn't it) and CEL came back on. I moved cylinder 3 and 4 coils into the #1 and 2 position, and now I'm getting just a P0301 code (along with CEL). What should I be doing next?

 

We need to start with when does the misfire occur?

All the time?
Cold start?
Idle?
Under load?

 

Good question. It mostly starts and idles rough. Driving it, I can feel no difference. In performing the diagnostics with the plugs and coils the first time the CEL came on immediately, and the next time it didn't after a 20 mile trip, but then came on the next day during a cold start.
The first time I started having this issue, the CEL came on driving home, on the highway.

 

That kind of suggests a headgasket that is seeping coolant in the cylinder.

First thing I would do is when the engine is cold pull the plugs, pressurize the cooling system with a pressure tester, and look in the cylinders with a borescope for coolant entering.

Eric O just posted a good video on doing this on a Honda, it has a pretty bad case but any coolant entering a cylinder is a fail.
https://www.youtube.com/watch?v=Rurhi-IGaiU

 

How many miles on the truck?

 

Truck has 174K on it. Really, the only time I feel anything unusual is at idle.

 

So, the saga continues. Plugs replaced. Coils swapped location, but the misfire stayed with cylinder 1. One day on a short drive, the engine lacked any power and barely made it up a hill, Turned off the vehicle and started it back up and it ran fine. Replaced the coils. Another P0301 code. No coolant seepage, ruled out a head gasket. Compression test on cylinders, fine. Could I have a valve timing or sensor issue??

 

You may have a mechanical failure with respect to the #1 piston cylinder head.

Broken valve, broken valve spring, etc....