P0301 and P2441

Was driving home last night after a full day of rain and suddenly lost most of my oomph, a slight shaking, and a flashing check engine light. Codes were P0301 (misfiring first cylinder) and P2441 (air system switching valve stuck closed bank 1). Most other threads I’ve found had this covered under warranty. I have an ‘08 with 333,000 miles on it so I doubt that’s a reality for me. Any suggestions on potential simple fixes for the P2441? Is it time to retire this truck?

 

I think it was only an extended campaign for the 1GR-FE Engine starting in 2012 which was the first year for the air pump system.