Play in between left front wheel and rack & pinion... 2000 PreRunner

Really hard to say from here, in theory a definate "maybe". You may need an alignment now or did before the slop developed and there are a lot of other "if's". The slop allowed by a worn guide will allow for fluctuation in toe values. It all depends on how things settle with the new goods. New bushings can also affect toe numbers.
The driver side toe value will be the most affected by the guide while bushings will affect both sides.

AND there is no such thing as "rack guide clearance", much less a spec for it.

 

Absolutely.